Ashton and coworkers found that the most common reason for discontinuation was lack of efficacy (reported by 44%) in 210 patients who had been previously treated for depression. This appears to confirm the clinical impression that many patients intentionally stop antidepressants as soon as they can. However, many patients stop antidepressants intentionally when they start to feel better. In fact, 2 studies found that a third of patients stop within 3 months, citing feeling better as the reason, and 55% stop when feeling better within 6 months. Thus, both successful and unsuccessful treatment often lead to patient-initiated discontinuation.