Friday, June 27, 2008

AHS meeting news: research on new medications


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In addition to research findings on two types of devices for treatment of migraine (TMS and ONS), studies on medications in development are also being presented at the 50th Annual American Headache Society scientific meeting this week: Tezampanel and MK9074.

Research on a drug called Tezampanel will be presented on Saturday. Tezampanel is being developed as an acute treatment for migraine disease. It has been found to be as effective as Imitrex when administered by injection and more effective than placebo in reliving the pain and symptoms associated with migraine attacks.

Tezampanel is an
ionotropic glutamate receptor antagonist. Glutamate is an amino acid that is necessary in a health body, but too much glutamate may play a factor in the development of a number of diseases and conditions. By targeting excess glutamate, researchers hope a drug like Tezampanel can end a migraine attack.

Research on another drug being developed to abort migraine attacks, currently known only as MK0974, will be presented at the meeting.

MK0974 works to stop a migraine by preventing release of a chemical called CRGP, which is thought to cause pain by promoting inflammation in the brain. Researchers hope that by preventing CRGP from being released they can stop the pain of a migraine attack.

MK0974 is said to be better at reducing the pain and other symptoms of a migraine attack than triptans (such as Imitrex, Relpax and Maxalt) and similarly well tolerated.

As more information about these two medications becomes available I will share it with you here.

Sources:
TorreyPines Therapeutics to Present Tezampanel Data at 50th Annual Scientific Meeting of American Headache Society
TorreyPines Therapeutics - Tezampanel and NGX426
MK0974 A New Migraine Treatment
Breakthrough in Migraine Therapy

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